Creon dose for adults. Creon - instructions for use, indications, dosage for children and adults, side effects, analogues and price. Is it possible to take medicine continuously
Creon is an enzyme drug that improves digestive processes. The drug can be used in both adults and children. Creon instructions for use of the drug describes the features of its use, dosage, indications, adverse reactions. Before using it, you should consult a doctor and study the proposed instructions.
Kreon has trade names: Creon 10000, 25000, 40000, international - Pancreatin.
The active ingredient in Creon is pancreatin, which contains a combination of key enzymes derived from animals (lipase, amylase, protease). Under their influence, the processes of splitting fats, proteins, carbohydrates and their subsequent absorption are improved. Thanks to this, the work of the digestive tract is facilitated, the functions of the organs of the digestive system are normalized.
When it enters the intestines, the Creon capsule quickly dissolves, releasing active minimicrospheres.
Thanks to minimicrospheres, there is a better distribution of the active substance in the intestinal contents, which helps its effect on the food bolus.
Auxiliary substances are:
- dimethicone;
- macrogol;
- dubutyl phthalate;
- liquid paraffin;
- methyl hydroxypropyl cellulose phthalate.
The hard gelatin shell consists of iron dyes - yellow, black, red oxide, directly gelatin, sodium lauryl sulfate, titanium dioxide.
Creon is produced in the form of hard gelatin capsules with a transparent shell that dissolves directly in the intestine. It is sometimes erroneously called the form of the drug tablets. Varieties of the drug differ in the amount of the incoming main component of pancreatin. Therefore, Creon 10000 contains 150 mg of pancreatin, Creon 25000 - 300 mg, Creon 40000 - 400 mg.
Capsules are packaged in 10, 25 pieces in blisters or 20, 50 pieces in bottles. Blisters, in turn, are packed in 2, 4 pieces in a pack.
Creon is used as a replacement therapy for inadequate performance of its enzyme-forming functions by the pancreas.
This condition occurs with the following diseases:
- Chronic inflammatory process in the pancreas (pancreatitis).
- Cystic fibrosis (hereditary disease resulting from gene mutation and affecting the glands of external secretion).
- Malignant neoplasms of the pancreas, also as a result of the closure of the lumen of the ducts due to existing neoplasms.
- Shwachman-Diamond syndrome (a genetic pathology manifested by a disorder of the secretory function of the pancreas).
- Decreased ability to form enzymes in the elderly.
The drug is also used as a symptomatic treatment for the following pathologies:
- After surgical interventions on the stomach (complete or partial removal of it).
- Cirrhosis of the liver (growth of dense connective tissue).
- Obstruction of the ducts of the biliary system.
- After surgery to remove gallbladder.
- With lesions of the final sections of the small intestine.
Also, as a symptomatic therapy, the drug is used with an excessive increase in the number of bacteria in the small intestine, cholestatic hepatitis (a disease associated with obstruction of the outflow of bile and its accumulation in the liver), duodeno- and gastrostasis (difficulties in evacuating food from the stomach and duodenum due to decreased motility of data organs).
The drug can also be prescribed in situations of nutritional errors in people with normal functioning of the digestive system (with overeating, excessive consumption of fatty foods, irregular meals, etc.).
According to the instructions, the use of Creon is contraindicated in acute pancreatitis or its acute course, with individual intolerance to the components present in the composition of the drug and animal pancreatin.
Creon should be used only after consultation with a specialist. With prolonged use in adults and children, it is necessary to regularly examine the attending physician.
Since there are no clinical data on the use of Creon in pregnant women, it is used with caution in this group of people, in cases where the expected result from therapy for a woman is higher than the likely risks for a child. Studies of porcine pancreatic enzymes in animals have not revealed a detrimental effect on the process of formation and development of the fetus and on the reproductive system. It is not contraindicated to take Creon while breastfeeding. The conducted studies did not show the harmful effects of the drug on the child through breast milk.
The drug is easily tolerated by patients, only in exceptional cases the following adverse reactions may occur:
- soreness of the abdomen;
- nausea;
- vomit;
- stool changes, in the form of diarrhea or constipation;
- allergic manifestations (rashes, itching, redness).
To prevent constipation when taking the drug should be observed sufficient drinking regimen(at least 2 liters of fluids daily).
Long-term use of the enzyme preparation in high dosages in some cases leads to narrowing of the lumen of the ileum and appendix, causes the occurrence of colitis (inflammatory diseases of the large intestine). Therefore, when treating these diseases with a drug in high doses, any unpleasant manifestations in abdominal cavity.
The Creon capsule is drunk completely during a meal, washed down with a small amount of liquid.
Creon 10000 is recommended for use in children. The selection of dosage in this case is carried out depending on the age of the child, the severity of the course of the disease, the type used diet food. In most cases, it is recommended to take some of the medicine before meals, the remaining dose during meals.
Usually treatment begins with a dosage of 10,000 - 25,000 units. The dose may increase with the appearance of steatorrhea (increased fat content in feces with disorders of their digestion processes) and other deterioration.
In the treatment of cystic fibrosis in children, the dosage of the drug is selected based on the proportion of the patient's body weight. In children under 4 years of age, 1000 units of lipase per kilogram of body weight are prescribed, over this age - 500 units of lipase per kilogram of body weight at each meal.
Creon 25000 is used in the treatment of other pathological conditions associated with impaired synthesis of pancreatic enzymes. In this case, the dosage is selected individually, taking into account the severity of the course of the disease, the patient's dietary habits, etc.
Creon 40000 is intended for use by adult patients. The appointment is also based on the severity of the course of the disease, the individual characteristics of the patient.
According to the instructions for the drug Creon, use in children with impaired swallowing functions is done by opening the capsule and mixing the internal contents with liquids or food that does not require chewing. The resulting mixture is not subject to long-term storage, so it must be used immediately for a single dose. Containing microspheres must not be crushed, chewed or added to acidic foods - all this will cause damage to their capsule, which protects against the effects of acidic stomach contents.
The dose of Creon can vary from 25,000 to 75,000 during the main meal, and range from 5,000 to 25,000 during snacks or light meals.
With an overdose of an enzyme drug, the content of uric acid in the blood may increase, followed by the accumulation of its salts and the deposition of kidney stones. It is recommended to stop the drug immediately and seek medical help.
Interactions of Creon with other drugs have not been identified. However, when taking other drugs, be sure to inform your doctor.
In case of malfunctions in the digestive processes in children, Creon 10000 can be prescribed. One capsule contains a daily dosage, which is divided into several meals. For newborns, the drug is prescribed with an indication of the dosage, regimen and duration of treatment. Parents are often concerned about the question of how to give medicine if the child cannot swallow - this should also be explained in detail by the attending doctor. Creon is prescribed for newborns with constant colic, bloating, diarrhea or constipation with particles of undigested food.
Creon's analogs
The drug has many analogues with a single active ingredient - pancreatin.
The following drugs can be distinguished:
- Pancreatin. Unlike Creon, it is available in tablets, and the content of the active substance is also arbitrary. Pancreatin begins to act already in the stomach and, reaching the intestines, it becomes ineffective, i.e. does not fulfill its functions in full. The price of this drug is much lower, but it has more disadvantages.
- Panzinorm. It is an absolute analogue and has no less efficiency in comparison with Creon.
- Mezim Forte.
- Gastenorm Forte.
- Festal.
These funds have an identical therapeutic effect, but may differ in cost and dosage.
The question of replacing the drug with an analogue is decided only by a specialist. Due to differences in dosages, the dose of the new drug is also selected individually by the treating doctor.
Creon 10000 is a unique drug that is used for disorders in the digestive system, not only for adults, but also for children.
Today, one in three suffers from stomach problems. Improper nutrition, abuse of alcohol and fatty foods, excess weight are the most common causes of disorders in the digestive system.
Improper eating behavior is the cause of insufficiency of the exocrine function of the pancreas. Normally, juices are secreted in the amount necessary for the digestion of food, and if there is a deviation, there is a deficiency of vitamins and serious health problems, the solution of which requires the use of an enzyme preparation that allows the digestive process to be normalized. Creon 10000 belongs to one of these drugs.
The main characteristics of the drug
This drug is as follows: hard two-color capsules in a gelatin shell, inside of which there are light brown minimicrospherical granules.
One Creon capsule includes: 150 milligrams of pancreatin (from pig pancreas), 10,000 units of lipase, amylase, proteolytic enzymes.
Creon 10000 is an enzyme remedy that is used for a lack of enzyme production by the pancreas. Suitable for treatment of both children and adults.
The drug gradually dissolves in the gastrointestinal tract, and minimicrospheres with enzymes are mixed with the contents of the intestine and contribute to their better redistribution. In the small intestine, the membrane dissolves, and enzymes are released, subsequently proteins, fats and carbohydrates are broken down. Thus, due to enzymes, our body is saturated with useful substances and trace elements.
Indications for use
Insufficient exocrine function of the pancreas in children and adults, caused by all kinds of diseases of the digestive system, as well as:
- cystic fibrosis;
- pancreatitis;
- gastrectomy;
- pancreatic cancer.
Application by children
The drug Creon for children is prescribed for a lack of enzymes as a result of violations of the physiological development of the digestive system. There are complaints about the instability of the stool, increased gas formation, heaviness after eating, belching, and so on. Such children eat little, are sickly, have a lack of weight. Creon 10000 helps to improve the digestion of food due to the enzymes it contains - compounds that take part in the process of splitting nutrients: proteins, fats and carbohydrates to the smallest, which enter the bloodstream.
Even the smallest children - infants, can be given the drug Creon. It is considered the safest and most acceptable means for them.
How to take medicine for a baby? Creon 10000 is prescribed by a doctor in small doses for a short period of time in order to avoid disruptions in the natural functioning of the pancreas. When prescribing, the degree of the disease and the age of the child are taken into account.
If at all Small child unable to swallow such large capsules, pour the contents into milk or baby food. Make sure the liquid is not too hot! Divide the daily dose of the drug into 3 parts and give the baby the first time - before meals, the second time - during meals, the third time - after meals.
This remedy is usually well tolerated by children. In rare cases, there may be side effects, it depends on the characteristics of the organism of a particular person. It is important that it is prescribed to be used by allergic children.
Results after application
With the systematic treatment with Creon, positive changes in the processes of digestion, complete assimilation of useful substances are observed. Children quickly gain weight, intestinal dysfunction is eliminated, flatulence and intestinal colic disappear.
Reviews of mothers about the use of Creon by their children confirm its effectiveness and benefits. They distinguish Creon among other enzyme medicines and note the solution to digestive problems: it eliminates painful in the stomach, normalizes stools, and eliminates belching.
How to use
Creon dosing involves taking into account individual factors: the intensity of disturbances in the digestion of food and the composition of food consumed, the weight of a person. Children under 4 years of age are prescribed 1000 units per day. lipases per kilogram of body weight. Children from 4 to 12 years old 500 IU. for every kg. Adult patients 10000-40000 IU. with every meal.
Take the drug inside, at the time of eating or after a meal. Swallow whole tablets, do not crush or bite them - this will damage their enteric coating and cause irritation of the mucous membrane. Take the capsules with large amounts of liquid, especially if you are dehydrated.
If swallowing is difficult (in the elderly), it is necessary to open the capsule and mix the minimicrospheres contained with a non-hard food with a sour taste or drink it with an acidified liquid. Such products include: yoghurts, juices, jelly. Do not store food mixed with medicine, but only eat freshly prepared food.
Contraindications
Individual intolerance to the components, in which the doctor prescribes similar enzyme preparations, inflammation of the pancreas, exacerbated or acute pancreatitis. In such cases, deterioration of the patient's condition can be observed.
With long-term treatment of children with Creon, consult a specialist regularly.
Side effects are very rare. However, there are complaints of abdominal pain, nausea, vomiting, constipation and diarrhea, rash and itching, and allergies.
After prolonged use, you can quickly gain excess body weight, so you must follow the diet prescribed by your doctor.
When using Creon by children, no special side effects were found, and if any did occur, they were similar to the reactions of adults.
Storage conditions
Creon 10000 is available without a doctor's prescription. You need to store the drug, tightly closing the container, the temperature should be no more than 30 degrees, the shelf life is about two years. Opened package no more than six months. Keep out of reach of children.
Some Features
The drug does not affect the ability to drive. Effects on the fetus and the course of pregnancy have not been studied. The combination with other drugs has not been studied.
In patients with cystic fibrosis, taking large amounts of pancreatin, strictures of the colon and cecum were detected. If you notice unusual changes in the abdomen, immediately undergo a medical examination.
Analogues
Many medications have analogues - products with similar components in the composition and having a similar therapeutic effect. Creon has these: Mezim, Festal, Pancreatin.
Analogues and the original drug have a difference in price. At a cost, analogues are much cheaper, but doctors advise using Creon. This can be explained by the exact ratio of medicinal components and the absence of bile acid in the composition, therefore, such drugs are more effective and can be taken by people with biliary tract diseases.
Composition and form of release
Creon ® 10000
Creon ® 25000
in a blister 10 pcs.; in a cardboard pack 2 blisters; in a blister 25 pcs.; in a pack of cardboard 2 or 4 blisters; in polyethylene bottles of 20 and 50 pieces; in a pack of cardboard 1 bottle.
Description of the dosage form
Bicolor hard gelatin capsules (brown opaque cap and clear colorless base).
Capsule contents: Beige enteric-soluble mini-microspheres.
pharmachologic effect
pharmachologic effect- replenishing the deficiency of pancreatic enzymes.Pharmacodynamics
An enzyme preparation that improves digestion. Pancreatic enzymes, which are part of the drug, facilitate the breakdown of proteins, fats, carbohydrates, which leads to their complete absorption in the small intestine. Capsules containing enteric-coated mini-microspheres dissolve rapidly in the stomach, releasing hundreds of mini-microspheres. The aim of the multi-unit dose principle is to mix the mini-microspheres with the intestinal contents, and ultimately a better distribution of the enzymes after their release within the intestinal contents.
Pharmacokinetics
When the mini-microspheres reach the small intestine, the enteric coating breaks down, releasing enzymes with lipolytic, amylolytic, and proteolytic activities that break down fats, starches, and proteins.
Indications for Creon ® 10000
replacement therapy for insufficiency of exocrine pancreatic function in cystic fibrosis, chronic pancreatitis, pancreatectomy, pancreatic cancer, duct obstruction (pancreatic ducts or common bile duct) due to neoplasm, Shwachman-Diamond syndrome, in old age;
symptomatic therapy of digestive disorders with partial resection of the stomach (Billroth-I / II), total gastrectomy; after cholecystectomy, with duodeno- and gastrostasis, biliary obstruction, cholestatic hepatitis, cirrhosis of the liver, pathology of the terminal part of the small intestine, excessive bacterial growth in the small intestine.
Contraindications
increased individual sensitivity to the components of the drug;
acute pancreatitis;
exacerbation of chronic pancreatitis.
Use during pregnancy and lactation
Due to the lack of sufficient data on the safety of the use of pancreatic enzymes in women during pregnancy and lactation, the drug should be prescribed to pregnant women and breastfeeding mothers only if the expected benefit to the mother exceeds possible risk for the fetus or child.
Side effects
Allergic reactions, rarely - diarrhea, constipation, discomfort in the stomach, nausea.
Interaction
There are no reports of interaction with other drugs.
Dosage and administration
inside. The dose is selected individually depending on the severity of the disease and the composition of the diet. It is recommended to take 1/3 or 1/2 of a single dose at the beginning of a meal, the rest with a meal. When swallowing is difficult (for example, in young children or elderly patients), the capsules are carefully opened, and the mini-microspheres are added to liquid food that does not require chewing, or taken with liquid. Any mixture of Mini Microspheres with food or liquid should not be stored and should be taken immediately after preparation. Crushing or chewing mini-microspheres, as well as adding them to food with a pH above 5.5, leads to the destruction of their shell, which protects against the action of gastric juice.
In cystic fibrosis, the dose depends on body weight and is at the beginning of treatment in children under 4 years old - 1000 lipase units / kg for each meal, over 4 years - 500 lipase units / kg during meals. The dose depends on the severity of the symptoms of the disease, the results of the control of steatorrhea and the maintenance of a good nutritional status. In most patients, the dose should not exceed 10,000 IU/kg/day.
In other conditions accompanied by exocrine pancreatic insufficiency, the dose is set taking into account the individual characteristics of the patient (degree of indigestion, fat content in food). The dose with the main meal (breakfast, lunch and dinner) is 20,000-75,000 units of lipase EF, at the time of admission light snack- 5000-25000 U EF of lipase.
The usual initial dosage of Creon ® is 10,000-25,000 units of lipase EF with the main meal. To reduce steatorrhea and maintain the optimal condition of the patient, it is possible to increase the dose. According to the usual clinical practice, the patient should receive with food at least 20,000-50,000 units of lipase EF.
Overdose
Symptoms: hyperuricuria, hyperuricemia.
Treatment: drug withdrawal, symptomatic therapy.
special instructions
In patients with cystic fibrosis who received high doses of pancreatin preparations, strictures of the ileum and caecum, colitis are described. In studies by the "case-control" method, no data were obtained indicating a relationship with Creon and the occurrence of fibrosing colonopathy. As a precautionary measure to rule out colonic involvement in patients with cystic fibrosis, it is recommended that any unusual symptoms or abdominal changes be monitored, especially if the patient is taking more than 10,000 units of lipase/kg/day.
The drug does not affect the ability to drive a car and to control machines and mechanisms.
Storage conditions for Creon ® 10000
At a temperature not higher than 20 °C.Keep out of the reach of children.
Shelf life of Creon ® 10000
enteric capsules 10,000 IU - 2 years. After opening - 3 months.
capsules 300 mg - 3 years. After opening the package - 3 months.
Do not use after the expiry date stated on the packaging.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| C25 Malignant neoplasm of pancreas | VIPoma |
| Glucagonomas | |
| Carcinoid tumor of the pancreas | |
| Locally advanced adenocarcinoma of the pancreas | |
| Inoperable pancreatic cancer | |
| Tumors of the pancreas | |
| Tumors of the pancreas, exocrine | |
| Tumors of the pancreas, endocrine | |
| Pancreas cancer | |
| E84.1 Cystic fibrosis with intestinal manifestations | Cystic pneumatosis of the intestine |
| Cystic fibrosis of the pancreas | |
| Fibrosis of the pancreas | |
| K31.5 Duodenal obstruction | duodenal obstruction |
| K31.8 Other specified diseases of stomach and duodenum | Anacid state |
| K74 Fibrosis and cirrhosis of the liver | Inflammatory liver disease |
| Cystic fibrosis of the liver | |
| Edema-ascitic syndrome in liver cirrhosis | |
| Precirrhotic state | |
| Cirrhosis of the liver with portal hypertension | |
| Cirrhosis of the liver with ascites | |
| Cirrhosis of the liver with ascites and edema | |
| Cirrhosis of the liver with portal hypertension | |
| Cirrhosis of the liver with portal hypertension and edematous-ascitic syndrome | |
| Cirrhosis of the liver with symptoms of portal hypertension | |
| Cirrhotic ascites | |
| Cirrhotic and precirrhotic state | |
| K83.1 Obstruction of bile duct | Biliary obstruction |
| Gallstone obstruction | |
| Itching with partial obstruction of the biliary tract | |
| Obstruction of the common bile duct | |
| Recurrent benign intrahepatic cholestasis | |
| cholestasis | |
| cholestatic hepatitis | |
| cholestatic syndrome | |
| K86.1 Other chronic pancreatitis | Exacerbation of chronic pancreatitis |
| Pancreatitis recurrent | |
| Pancreatitis with exocrine insufficiency | |
| Chronic pancreatitis | |
| Chronic pancreatitis | |
| K86.8 Other specified diseases of pancreas | Blockage of the pancreatic and bile ducts |
| Obstruction of the pancreatic ducts | |
| Fistula of the pancreas | |
| K86.8.0* Pancreatic hypofunction, exocrine | Exocrine pancreatic insufficiency |
| Hypofunction of the pancreas | |
| pancreatic dysfunction | |
| Violation of the exocrine function of the pancreas | |
| Pancreatic dysfunction | |
| Violation of the exocrine function of the pancreas | |
| Insufficiency of enzyme formation in the pancreas | |
| Pancreatic insufficiency | |
| Exocrine pancreatic insufficiency | |
| Pancreatopathy | |
| Shwachman-Diamond Syndrome | |
| Enzyme deficiency of the pancreas | |
| K91.5 Postcholecystectomy syndrome | Condition after removal of the gallbladder |
| R54 Old age | External signs of aging |
| age-related eye disease | |
| Age-related visual impairment | |
| Age related vascular disease | |
| age constipation | |
| Age-related changes in visual acuity | |
| Age-related involutional changes in the brain | |
| age disorders | |
| Age-related hearing loss | |
| Gerontological practice | |
| dementia senile | |
| Calcium and vitamin D3 deficiency in the elderly | |
| Brain disease of a vascular and age-related nature | |
| involutional depression | |
| Involutional depressions | |
| Correction of metabolism in the elderly and senile age | |
| Malnutrition in the elderly and senile age. | |
| Conduct disorders in the elderly | |
| Senile dementia | |
| Senile dementia | |
| Senile depression | |
| Senile colpitis | |
| Senile psychosis | |
| Age involutional syndrome | |
| Hearing loss age | |
| Aging | |
| Brain aging | |
| Body aging | |
| senile dementia | |
| Senile age | |
| Senile involutional psychosis | |
| senile psychosis | |
| Memory impairment in elderly patients | |
| Z100* CLASS XXII Surgical practice | Abdominal surgery |
| Adenomectomy | |
| Amputation | |
| Angioplasty of coronary arteries | |
| Angioplasty of the carotid arteries | |
| Antiseptic skin treatment for wounds | |
| Antiseptic hand treatment | |
| Appendectomy | |
| Atherectomy | |
| Balloon coronary angioplasty | |
| Vaginal hysterectomy | |
| Crown bypass | |
| Interventions on the vagina and cervix | |
| Bladder interventions | |
| Intervention in the oral cavity | |
| Restorative and reconstructive operations | |
| Hand hygiene of medical personnel | |
| Gynecological surgery | |
| Gynecological interventions | |
| Gynecological operations | |
| Hypovolemic shock during surgery | |
| Disinfection of purulent wounds | |
| Disinfection of wound edges | |
| Diagnostic interventions | |
| Diagnostic procedures | |
| Diathermocoagulation of the cervix | |
| Long-term surgery | |
| Replacement of fistula catheters | |
| Infection during orthopedic surgery | |
| Artificial heart valve | |
| cystectomy | |
| Brief outpatient surgery | |
| Short-term operations | |
| Short term surgical procedures | |
| Cricothyrotomy | |
| Blood loss during surgery | |
| Bleeding during surgery and in the postoperative period | |
| Culdocentesis | |
| Laser coagulation | |
| Laser coagulation | |
| Laser coagulation of the retina | |
| Laparoscopy | |
| Laparoscopy in gynecology | |
| CSF fistula | |
| Minor gynecological surgeries | |
| Minor surgical interventions | |
| Mastectomy and subsequent plasty | |
| Mediastinotomy | |
| Microsurgical operations on the ear | |
| Mucogingival operations | |
| Suturing | |
| Minor surgical interventions | |
| Neurosurgical operation | |
| Immobilization of the eyeball in ophthalmic surgery | |
| Orchiectomy | |
| Complications after tooth extraction | |
| Pancreatectomy | |
| Pericardectomy | |
| The period of rehabilitation after surgical operations | |
| The period of convalescence after surgical interventions | |
| Percutaneous transluminal coronary angioplasty | |
| Pleural thoracocentesis | |
| Pneumonia postoperative and post-traumatic | |
| Preparation for surgical procedures | |
| Preparing for surgery | |
| Preparation of the surgeon's hands before surgery | |
| Preparing the colon for surgery | |
| Postoperative aspiration pneumonia in neurosurgical and thoracic operations | |
| Postoperative nausea | |
| Postoperative bleeding | |
| Postoperative granuloma | |
| Postoperative shock | |
| Early postoperative period | |
| Myocardial revascularization | |
| Resection of the apex of the tooth root | |
| Resection of the stomach | |
| Bowel resection | |
| Uterine resection | |
| Liver resection | |
| Resection of the small intestine | |
| Resection of a part of the stomach | |
| Reocclusion of the operated vessel | |
| Bonding tissue during surgery | |
| Removal of stitches | |
| Condition after eye surgery | |
| Condition after surgery | |
| Condition after surgical interventions in the nasal cavity | |
| Condition after resection of the stomach | |
| Condition after resection of the small intestine | |
| Condition after tonsillectomy | |
| Condition after removal of the duodenum | |
| Condition after phlebectomy | |
| Vascular surgery | |
| Splenectomy | |
| Sterilization of the surgical instrument | |
| Sterilization of surgical instruments | |
| Sternotomy | |
| Dental operations | |
| Dental intervention on periodontal tissues | |
| Strumectomy | |
| Tonsillectomy | |
| Thoracic surgery | |
| Thoracic operations | |
| Total gastrectomy | |
| Transdermal intravascular coronary angioplasty | |
| Transurethral resection | |
| Turbinectomy | |
| Removal of a tooth | |
| Cataract removal | |
| Removal of cysts | |
| Tonsil removal | |
| Removal of fibroids | |
| Removal of mobile milk teeth | |
| Removal of polyps | |
| Removal of a broken tooth | |
| Removal of the body of the uterus | |
| Suture removal | |
| Urethrotomy | |
| CSF fistula | |
| Frontoethmoidogaimorotomy | |
| Surgical infection | |
| Surgical treatment of chronic leg ulcers | |
| Surgery | |
| Surgery in the anus | |
| Surgical operation on the large intestine | |
| Surgical practice | |
| surgical procedure | |
| Surgical interventions | |
| Surgical interventions on the gastrointestinal tract | |
| Surgical interventions on the urinary tract | |
| Surgical interventions on the urinary system | |
| Surgical interventions on the genitourinary system | |
| Surgical interventions on the heart | |
| Surgical manipulations | |
| Surgical operations | |
| Surgical operations on the veins | |
| Surgical intervention | |
| Surgical intervention on the vessels | |
| Surgical treatment of thrombosis | |
| Surgery | |
| Cholecystectomy | |
| Partial resection of the stomach | |
| Transperitoneal hysterectomy | |
| Percutaneous transluminal coronary angioplasty | |
| Percutaneous transluminal angioplasty | |
| Bypass coronary arteries | |
| Tooth extirpation | |
| Extraction of milk teeth | |
| Pulp extirpation | |
| extracorporeal circulation | |
| Tooth extraction | |
| Extraction of teeth | |
| Cataract Extraction | |
| Electrocoagulation | |
| Endourological interventions | |
| Episiotomy | |
| Ethmoidectomy |
Man is an omnivore. Our digestive system handles both plant and animal foods. For this, through a long evolution, the digestive glands and their various juices were formed. So, bile helps to dissolve (emulsify) fats, and pancreatic lipase digests them.
Gastric juice is a highly aggressive acidic environment that can dissolve many organic compounds, and the pepsin enzyme contained in gastric juice starts digestion. (Strictly speaking, digestion begins at oral cavity- the amylase enzyme contained in saliva begins the breakdown of starch and carbohydrates).
The pancreas plays an important role in digestion. It produces enzymes that can break down proteins, fats and carbohydrates. These are amylase, lipase and peptidase. These highly aggressive molecules "pounce" on any substances that appear in front of them. Therefore, inside the gland, they are stored in an inactivated form, and are activated in the duodenum.
But sometimes it crashes. In acute pancreatitis, this caustic juice is inside the gland itself, and begins to digest it. There is a stage of autolysis, in which there are very severe pain. After acute pancreatitis, iron often loses its ability to produce "quality" enzymes, and does not work efficiently enough. As a result, there is an enzymatic insufficiency of the pancreas.
How does pancreatic insufficiency manifest itself?
Creon 10000 photo
People with insufficiency of external secretion of pancreatic enzymes develop digestive insufficiency. They cannot fully digest proteins, fats and carbohydrates. As a result, for example, the phenomenon of creatorrhea and steatorrhea occurs. In the first case, undigested muscle fibers can be found in the feces after eating meat, and in the second, neutral, undigested fat, due to a lack of pancreatic lipase.
As a result, there are complaints about the instability of digestion, bloating, intolerance to certain types of food, alternating constipation and diarrhea. This leads to chronic damage to the intestines - secondary dysbacteriosis develops, beriberi (after all, many vitamins are produced by microbes living inside us), immunity decreases.
It is for the correction of these disorders that enzymatic preparations are intended, to which Creon belongs.
Active ingredient Creon and effects on the body
What helps "Creon" and its analogues? Unlike many drugs that affect individual links in pathogenesis, Creon simply gives the body what it lacks, namely enzymes. Of course, this drug does not contain human enzymes, since their production using genetic and molecular engineering would be too expensive. Enzymes from cattle are quite sufficient. The following enzymes are isolated from the tissues of the pancreas of slaughtered animals:
- pancreatin (a mixture of enzymes representing a gray - yellow powder);
- amylase (to break down carbohydrates)
- lipase (for fats)
- protease (for proteins).
The drug is available in an enteric coating. After all, normally these enzymes work in the duodenum, where the environment is much more alkaline than in the stomach.
If you do not protect the enzymes with a shell, but take them in powder, then once in the stomach, they are simply inactivated and digested, because the enzymes themselves - catalysts for biochemical reactions - are protein molecules. Therefore, Creon capsules are taken only as a whole.
The mechanism of action is very simple: if you take a few capsules with food, then the enzymes, released in the intestines, will begin to "help" the pancreas cope with the digestion of food. That is why all enzyme preparations are taken with food. What are the indications for taking Creon?
Indications for use
"Creon" and its analogues are used in all situations where primary or secondary insufficiency in the synthesis of pancreatic enzymes develops, or there is a mechanical obstacle to their entry into the intestine. The most common situations are:
- chronic pancreatitis, except for the stage of exacerbation;
- cystic fibrosis in children;
- resection of the pancreas;
- malignant neoplasms of the pancreatoduodenal region;
- obstruction (blockage) and narrowing of the excretory ducts of the pancreas;
- pathological formations of the common bile duct;
- in the elderly and senile age (due to the general involution of enzyme systems);
- after operations on the stomach and gallbladder;
- V complex therapy chronic cholecystitis, hepatitis and cirrhosis (due to insufficient secretion of bile).
There are other indications for the use of the drug "Creon" and analogues, which are determined by the attending physician, depending on the diagnosis.
For example, a healthy person can also take this remedy in order to avoid painful sensations after the New Year's feast. "Creon" will help you quickly cope with fatty, fried foods with less stress on your own pancreas.
Instructions for use Creon and dosage
How much and in what cases to take?
"Creon" is produced in various degrees of "strength", which is expressed in units of enzymatic activity. The higher the number, the more active the drug. The following dosages of the drug are currently available:
- 10,000 units (capsule 0.15 g, or 150 mg, in a package of 20 capsules);
- 25,000 units (capsule 0.3 g, or 300 mg, in a pack of 20 capsules);
- 40,000 units (50 capsules in a bottle).
"Creon" and its analogues are "democratic" drugs. Since the remedy is indicated for replacement therapy, the drug should not be taken once: this will not lead to anything.
How long can I take Creon 10000 and more concentrated analogues? At least for life. After all, its role is simple: the drug does not interfere with the work of the body, but simply adds what should be constantly produced in it, but is not produced due to a certain defect.
As for the use of the drug in pediatric practice, it is possible - there are no special contraindications. "Creon" 10000 for children is the most popular dosage, but adults, especially tall ones, need to use more concentrated varieties of the drug.
How to take Creon for adults and children? The most important thing is that the remedy is taken with food, and the food is washed down with a sufficient amount of liquid. After all, all enzymes work in the liquid phase. That is why, if you are in doubt about how to give Creon to a child, if the drug was missed during meals, then it is better not to take it (on an empty stomach). After all, if enzymes enter the intestines when there is no food, they will begin to harm the intestinal wall.
Contraindications
There are very few contraindications to taking enzyme preparations: this is acute inflammation, and exacerbation of chronic pancreatitis.
The use of Creon tablets is prohibited for two reasons: firstly, in acute pancreatitis and exacerbation, "hunger, cold and rest" is prescribed. Since food does not enter the intestines, then the enzymes that help break it down have nothing to do there either.
And secondly, in acute pancreatitis, enzymes are not friends, but worst enemies, because they cause autolysis, or self-digestion of gland tissues. And to help the disease destroy a vital organ, right, is not worth it.
In addition, the drug is contraindicated in case of allergy to its components. Although rare, it happens: although the enzymes of all mammals are very similar, they are still foreign protein molecules, and an allergic reaction can develop to them.
Side effect
As usual, the side effects are "an extension of the virtues." If you overdo it with the reception, then there may be a feeling of discomfort, diarrhea (diarrhea), or nausea with heartburn may develop. Therefore, taking "Creon", you need to gradually increase the dose to an acceptable state of health.
It must be said that in the treatment of chronic pancreatitis, Creon is taken while adhering to a diet. In that case, you can get by with a minimum dosage, and at the same time not have any side effects.
What can replace the drug?
Creon does not have generics - after all, a mixture of dried pork and beef pancreas is not a patented find. And, therefore, there is nothing to copy to other companies after the expiration of this patent. Analogues of "Creon" are possible only by group affiliation - the price is different for everyone, the reviews are approximately similar, and the instructions for use are almost identical. The most common drugs are:
- "Pancreatin";
- "Panzinorm";
- "Festal";
- "Enzistal";
- "Mezim", "Mezim - Forte";
- "Mikrazim";
- "Pangrol";
- "Penzital";
- "Pantsitrat".
Do not confuse drugs containing enzymes with drugs that normalize the motility of the gastrointestinal tract. So, "Motilium", (or domperidone) can also reduce discomfort and bloating in the abdomen, but the nature of this discomfort is completely different, and the drug itself acts on brain receptors, and has nothing to do with pancreatic enzymatic insufficiency.
Of all the above drugs, Creon is the most expensive. So, a package of 20 Creon 25000 capsules costs from 275 rubles, and domestic pancreatin (60 tablets) at the same dosage costs from 27 rubles. At the same time, the cleaning, the level of activity and the severity of the effect of Creon are very good. It is produced by Abbott Laboratories LLC, and deservedly won appreciation from both doctors and gastroenterological patients.
Almost every person in his life has encountered various digestive disorders associated with a lack of production of enzyme substances, which leads to pain symptoms, discomfort, painful sensation and burning sensation in the epigastric zone. To help the body cope with such unpleasant consequences, the attending physician usually prescribes drugs that contain digestive enzymes. One such remedy is the drug "Creon".
Description
The drug "Creon", reviews also testify to this, is used as a replacement treatment for violations of the pancreas. This is a combination drug, produced in the form of capsules with a hard gelatin shell, consisting of a dark brown cap and an uncolored base. Produced in polyethylene bottles of 20, 50 or 100 capsules.
Composition and form of release
The contents of each capsule is a set of specific pancreatic enzymes. Near the name of each type of drug, the number of thousands means how many units of lipase are contained in one capsule. There are three types of Creon capsules: 10, 25 and 40 thousand each.
The first type of capsules contains 0.150 g of pancreatic extract in the form of pancreatin, which includes 10 thousand units of the lipase enzyme, 0.6 thousand units of protease and 8 thousand amylase.
The second composition already contains 0.3 g of pancreatin, and the number of units of lipase is 25 thousand, protease - 1 thousand, amylase - 18 thousand.
The largest amount of pancreatin (0.4 g) is contained in the third form, the content of lipase is 40 thousand, 1.6 thousand protease and 25 thousand amylase.
Polyethylene glycol 400 is used as auxiliary components for the formation of cores in granules, and the shell is made from hydroxypropyl methylcellulose phthalate, etal (cetyl alcohol), selenium-containing dimethicone, citric acid ester and ethylene.
The basis of the capsule shell is formed by gelatin, with the addition of various dyes of iron oxide, titanium dioxide, sodium dodecyl sulfate.
Medication "Creon": patient reviews
This tool belongs to the drugs of a new generation, since it is produced in the form of enteric capsules with contents in the form of complex granules. Unlike the Creon drug, its analogues are produced in tablet form, which reduces the function of enzymes, which, when the tablet shell dissolves, enter the stomach and are exposed to hydrochloric acid. As a result, a small part of them reaches the intestines, where they must perform their function of breaking down proteins, fats and carbohydrates.
Thanks to the encapsulated form of release of the Creon drug, reviews of its best therapeutic effect can be heard from many patients who have switched to treatment with this drug. This medication has established itself as a fast-acting, effective drug, which is considered the best in its pharmacotherapeutic group.
The negative side of this drug is the rather high price and the use of capsules only for certain diseases, and not as a digestion accelerator when overeating. The human body very quickly adapts to receiving enzymes from the outside, and there is a decrease in the production of its own pancreatin by the pancreas, which leads to atrophy of this organ. Therefore, only a doctor, based on examinations and tests, can prescribe the drug "Creon". Reviews of its use for the preventive treatment of minor digestive problems say that it is better to use less strong enzyme preparations.
Analogues
In the pharmaceutical market, there have long been enzyme preparations produced in tablet form. The drug "Creon" analogues have the same composition of active enzymes contained in pancreatin, and they all help to digest food. The difference between a capsule remedy and tablets is the faster release of the active substance in the intestine, which allows you to start acting earlier. That is why it is considered more effective, respectively, and its cost is higher than that of similar drugs.
If there is not enough money to buy the expensive drug "Creon", analogues in the form of medicines "Panzinorm", "Pancreatin", "Mikrazim", "Pancrelipase" are sold in pharmacies at a lower price.
How does the drug work?
The content of the capsules consists of gastro-resistant granules in the form of mini-microspheres. The mechanism of action of the drug "Creon" is associated with the gradual splitting of the shell of larger granules first, and then small ones. Each large minimicrosphere is covered with a shell soluble in the stomach; after its destruction, smaller microspheres are released from each such granule, but already with an enteric shell. The dissolution of the coating of small granules allows the release of active ingredients that are mixed with food in the small intestine. This contributes to the lipid, protein or carbohydrate breakdown of fats, proteins and carbohydrates to amino acids, fatty acids, trihydric alcohol and monosaccharides, which facilitates the process of absorption through the intestinal wall into the blood.
Diseases that the drug treats
With substitution therapy in conditions of insufficient exocrine secretory work of pancreatic cells, the drug "Creon" is used. The use of this remedy is possible in cystic fibrosis, chronic inflammatory processes in the pancreas or when it is removed, in violation of the patency by tumors of the pancreatic or bile duct, malignant neoplasms, Shwachman-Diamond syndrome, with age-related violations of enzyme production.
It is used to eliminate symptoms in case of digestive disorders associated with the removal of the gallbladder, some sections in the intestine according to Billroth (I and II options), excision of the entire stomach, followed by the formation of an esophago-intestinal anastomosis, with a syndrome of slow release of the stomach cavity and slow food movement. through the lumen in the duodenum. It is used in patients with obstruction of the bile ducts, cholestatic hepatitis, cirrhosis of the liver, pathological changes in the terminal section and excessive growth of bacteria in the small intestine.
Dosages and rules of admission
The drug is intended for oral use. A single dose is divided in half or into three parts, half or a third of the dose is drunk before meals, and the remainder is taken with food. The dosage depends on the degree of the disease state and the components of the diet. The amount of lipase in one dosage should not be more than 10 thousand units when taking the drug "Creon". The course of treatment for this medicine the doctor establishes based on the dynamics and condition of the patient.
In order for the Creon drug to work correctly, it is recommended not to break the capsule shell, but to drink the whole one, using water for better swallowing.
If the patient, due to special reasons, cannot swallow the whole capsule, then the shell is divided into two parts and the granules are poured into liquid food or liquid with an acidic environment (less than 5), and then this mixture is swallowed. If the granules are chewed, crushed, or mixed with alkaline food, then the shell covering the mini-microspheres may collapse, which will lead to the loss of activity of their contents under the influence of gastric juice.
The dosage of lipase in case of insufficient work of the pancreas is determined by the degree of violation of its work and the amount of fat in the patient's diet. Its amount when used three times a day during breakfast, lunch and dinner ranges from 20-75 thousand units.
On early stages treatment, the amount of lipase in one dose should average from 10 to 25 thousand units, and then, depending on the condition, it is increased.
Treatment of children with Creon
Almost all newborn babies have malfunctions in the digestive system, due to its imperfection. This is manifested by difficulty in digesting food, colic, rare stools and subsequent dysbacteriosis. The reason is the insufficient production of digestive enzymes by the cells of the pancreas. To improve digestion, the doctor prescribes treatment with Creon for babies. Reviews of parents whose children were prescribed this medication testify to its effectiveness and safety of use. Food after taking the drug is better broken down in the intestines, the absorption of nutrients improves, the stool normalizes.
The drug "Creon" for children is very effective. The instruction describes the use of this remedy for chronic inflammation of the pancreas, when removing the diseased part of it, with digestive disorders, after irradiation, cystic fibrosis, abdominal distension, frequent diarrhea, obstruction of the ducts in the pancreas, after stomach surgery.
Children's dosages
Often doctors prescribe the drug "Creon" to children. The dosage of lipase per day for newborns should not exceed 10-15 thousand units. To give the baby this drug, you need to remove the granules from the gelatin capsule, add them to breast milk or milk formula at room temperature.
For children under 4 years of age with signs of cystic fibrosis, the dosage of lipase at the beginning of treatment is equal to 1 thousand units per kilogram of weight during each meal, for children over the age of 4 years it is 0.5 thousand units per kilogram of weight.
Taking the drug, as for adults, is divided into two stages, part of the dosage is given before meals, and the rest of the contents of the capsule are taken with food.
Medication price
Depending on the dosage of the Creon drug, the price will vary on average from 300 rubles per package with a dosage of lipase of 10 thousand units in one capsule, 600 rubles for a dosage of 25 thousand units and 1400 rubles for a dose of 40 thousand units. Price in different regions countries may vary.
